Publications (since 2012)...

A PACAP-activated network for secretion requires coordination of Ca (2+) influx and Ca (2+) mobilization. Chen X, Bell NA, Coffman BL, Rabino AA, Garcia-Mata R, Kammermeier PJ, Yule DI, Axelrod D, Smrcka AV, Giovannucci DR, Anantharam A. . bioRxiv. 2024 Jan 3;. doi: 10.1101/2024.01.03.574069. PubMed PMID: 38260572; PubMed Central PMCID: PMC10802325.

Membrane lipids couple synaptotagmin to SNARE-mediated granule fusion in insulin-secreting cells. Amos C, Kiessling V, Kreutzberger AJB, Schenk NA, Mohan R, Nyenhuis S, Doyle CA, Wang HY, Levental K, Levental I, Anantharam A+, Tamm LK+. (+co-corresponding authors) Mol Biol Cell. 2024 Mar 1;35(3):ar12. doi: 10.1091/mbc.E23-06-0225. Epub 2023 Dec 20. PubMed PMID: 38117594; PubMed Central PMCID: PMC10916878.

Phospholipase C-ε defines a PACAP-stimulated pathway for secretion in the chromaffin cell. Chen X, Coffman BL, Brindley RL, Galpin JD, Ahern CA, Currie KPM, Smrcka AV, Axelrod D, Anantharam A. J Neuroendocrinol. 2023 Nov;35(11):e13255. doi: 10.1111/jne.13255. Epub 2023 Mar 27. PubMed PMID: 36970756; PubMed Central PMCID: PMC10790106.

Synaptotagmin-7 facilitates acetylcholine release in splanchnic nerve-chromaffin cell synapses during nerve activity. Caballero-Florán RN, Bendahmane M, Gupta JP, Chen X, Wu, X, Morales A, Anantharam A+, Jenkins PM+. (+co-corresponding authors). Neurosci Lett. 2023 Feb 14:137129. doi: 10.1016/j.neulet.2023.137129.

PACAP and acetylcholine cause distinct Ca2+ signals and secretory responses in chromaffin cells. Morales AM, Mohan R, Chen X, Coffman BL, Bendahmane M, Watch L, West JL, Bakshi S, Traynor JR, Giovannucci DR, Kammermeier PJ, Axelrod D, Currie KPM, Smrcka AV+, Anantharam A+ (+co-corresponding authors). Journal of General Physiology. 2023 Feb 6;155(2). Epub 2022 Dec 20.

Stimulus-secretion coupling in the adrenal medulla. Anantharam A and Holz RW. Exocytosis: From Molecules to Cells Bristol (Chapter 12), UK: IOP Publishing; 2022. Chapter 12; p.1-17. 372p.

Exocytosis: From Molecules to Cells. Anantharam A and Knight JD, editors. Bristol, UK: IOP Publishing; 2022. 372p.

Distinct insulin granule subpopulations implicated in the secretory pathology of diabetes types 1 and 2. Kreutzberger AJB, Kiessling V, Doyle CA, Schenk NA, Upchurch CM, Elmer-Dixon M, Ward AE, Preobraschenski J, Hussain SS, Tomaka W, Seelheim P, Kattan I, Harris M, Liang B, Kenworthy AK, Desai BN, Leitinger N, Anantharam A, Castle JD, Tamm LK. eLife. 2020;9:e62506

Integrating Optical and Electrochemical Approaches to Assess Actions of Dynamin at the Fusion Pore. Smith K.A., Prantzalos E.R., Anantharam A. Methods in Molecular Biology. 2020;2159:163-178.

Synaptotagmin-7 enhances calcium-sensing of chromaffin cell granules and slows discharge of granule cargos. Bendahmane M*, Morales A*, Kreutzberger AJB, Schenk NA, Mohan R, Bakshi S, Philippe J, Zhang S, Kiessling V, Tamm LK, Giovannucci DR, Jenkins PM, Anantharam A. Journal of Neurochemistry. 2020 Sep;154(6):598-617.

TLR3 absence confers increased survival with improved macrophage activity against pneumonia. Suresh MV, Dolgachev VA, Zhang B, Balijepalli S, Swamy S, Mooliyil J, Kralovich G, Thomas B, Machado-Aranda D, Karmakar M, Lalwani S, Subramanian A, Anantharam A, Moore BB, Raghavendran K. Journal of Clinical Investigation Insights. 2019 Dec 5;4(23).

Unraveling the mechanisms of calcium-dependent secretion. Anantharam A, Kreutzberger AJB. Journal of General Physiology. 2019 Apr 1; 151(4): 417-434.

Perivascular Adipocytes Store Norepinephrine by Vesicular Transport. Ahmad M, Ferland D, Ayala-Lopez N, Contreras G, Darios E, Thompson J, Ismail A, Thelen K, Moeser A, Burnett R, Anantharam A, Watts S. Arteriosclerosis, Thrombosis, and Vascular Biology. 2019; Feb; 39(2): 188-199.

A simple supported tubulated bilayer system for evaluating protein-mediated membrane remodeling. Schenk N*, Dahl PJ*, Hanna M, Audhya A, Tall GG, Knight JD+, Anantharam A+. Chemistry and Physics of Lipids. 2018; Sep; 215: 18-28. (*co-first authors; +co-corresponding authors)

Phosphatidylinositol 4-Phosphate is a Major Substrate for GPCR-stimulated Phosphoinositide Hydrolysis. Gil de Rubio R, Malik S, Yule DI, Anantharam A, Smrcka AV. Science Signaling. 2018; Sep 11; 11 (547).

Synaptotagmin-7 is a high affinity calcium- sensor that serves multiple roles in regulated exocytosis. MacDougall DD, Lin Z, Chon NL, Jackman SL, Lin H, Knight JD+, Anantharam A+. Journal of General Physiology. 2018; Jun 4; 150(6):783-807. (+co-corresponding authors)

The synaptotagmin C2B domain calcium-binding loops modulate the rate of fusion pore expansion. Bendahmane M, Bohannon KP, Rao TC, Schmidtke MW, Bradberry MM, Abbineni P, Chon N, Tran S, Lin H, Chapman ER, Knight JD, Anantharam A. Molecular Biology of the Cell. 2018; Apr 1; 29(7): 834-845.

Synaptotagmin isoforms confer distinct activation kinetics and dynamics to chromaffin cell granules. Rao TC, Santana Rodriguez Z, Bradberry MM, Ranski AH, Dahl PJ, Schmidtke MW, Jenkins PM, Axelrod D, Chapman ER, Giovannucci DR, Anantharam A. Journal of General Physiology 2017; Aug 7; 149(8):763-780.

Food deprivation induces presynaptic plasticity in the autonomic nervous system. Holz RW, Anantharam A. Proceedings of the National Academy of Sciences. 2016; 113 (21): 5766-5767.

Distinct fusion properties of synaptotagmin-1 and synaptotagmin-7 bearing dense core granules. Rao TC, Passmore DR, Peleman AR, Das M, Chapman ER, Anantharam A. Molecular Biology of the Cell. 2014; 25(16):2416-27.

Lumenal Protein within Secretory Granules Affects Fusion Pore Expansion. Weiss AN, Anantharam A, Bittner MA, Axelrod D, Holz RW. Biophysical Journal. 2014; 107(1):26-33.

Imaging plasma membrane deformations with pTIRFM. Passmore DR, Rao TC, Peleman AR, Anantharam A. Journal of Visualized Experiments: JoVE 2014(86).

Real time investigation of plasma membrane deformation and fusion pore expansion using polarized TIRFM. Passmore DR, Rao T, Anantharam A. Methods in Molecular Biology 2014; 1174: 263-73.

Real-time imaging of plasma membrane deformations reveals pre-fusion membrane curvature changes and a role for dynamin in fusion pore expansion. Anantharam A, Axelrod D, Holz RW. Journal of Neurochemisty 2012; 122(4): 661-671.

Ultra-fast detection and quantification of brain signaling molecules with carbon fiber microelectrodes. Lama RD, Charlson K, Anantharam A, Hashemi P. Analytical Chemistry 2012; 84(19): 8096-101.